Striatal cholinergic receptor activation causes a rapid, selective and state‐dependent rise in cortico‐striatal β activity

• DOI: 10.1111/ejn.13906
• Publication Date: 2018-03-12T14:26:39Z
• Authors: Benjamin R. Pittm...; Allison Quach; Ali I. Mohammed; Michael Romano; Krishnakanth Kond...; Nancy J. Kopell; Xue Han; Michelle M. McCarthy
• Keywords: Male; Time Factors; Motor Cortex; Cholinergic Agonists; Corpus Striatum; Mice, Inbred C57BL; Mice; 03 medical and health sciences; 0302 clinical medicine; 616; Neural Pathways; Animals; Female; Receptors, Cholinergic; Beta Rhythm

AbstractCortico‐basal ganglia‐thalamic (CBT) β oscillations (15–30 Hz) are elevated in Parkinson's disease and correlated with movement disability. To date, no experimental paradigm outside of loss of dopamine has been able to specifically elevate β oscillations in the CBT loop. Here, we show that activation of striatal cholinergic receptors selectively increased β oscillations in mouse striatum and motor cortex. In individuals showing simultaneous β increases in both striatum and M1, β partial directed coherence (PDC) increased from striatum to M1 (but not in the reverse direction). In individuals that did not show simultaneous β increases, β PDC increased from M1 to striatum (but not in the reverse direction), and M1 was characterized by persistent β‐high frequency oscillation phase–amplitude coupling. Finally, the direction of β PDC distinguished between β sub‐bands. This suggests that (1) striatal cholinergic tone exerts state‐dependent and frequency‐selective control over CBT β power and coordination; (2) ongoing rhythmic dynamics can determine whether elevated β oscillations are expressed in striatum and M1; and (3) altered striatal cholinergic tone differentially modulates distinct β sub‐bands.