Adenosine A2A receptors modulate the dopamine D2 receptor‐mediated inhibition of synaptic transmission in the mouse prefrontal cortex

• DOI: 10.1111/ejn.13912
• Publication Date: 2018-03-23T19:27:54Z
• Authors: Joana I. Real; Ana Patrícia Simões; Rodrigo A. Cunha; Samira G. Ferreira; Daniel Rial
• Keywords: Sulpiride

Abstract Prefrontal cortex ( PFC ) circuits are modulated by dopamine acting on D 1 ‐ and 2 ‐like receptors, which pharmacologically exploited to manage neuropsychiatric conditions. Adenosine A 2A receptors (A R also control ‐related responses antagonists potential anti‐psychotic drugs. As tight antagonistic –D synergistic interactions occur in other brain regions, we now investigated the crosstalk between /D controlling synaptic transmission layers II / III V mouse coronal slices. Dopamine decreased transmission, a presynaptic effect based parallel increase paired‐pulse responses. inhibition was prevented R‐like antagonist sulpiride but not SCH 23390 mimicked agonist sumanirole, agonists of either 4 (A‐412997) or 3 PD 128907). antagonist, 58261, attenuated knockout mice. Accordingly, triple‐labelling immunocytochemistry experiments revealed co‐localization immunoreactivity glutamatergic vG luT1‐positive) nerve terminals . This reported positive interaction provides mechanistic justification for antagonists.