Spatial impact of microglial distribution on dynamics of dendritic spines

• DOI: 10.1111/ejn.14325
• Publication Date: 2018-12-26T10:34:20Z
• Authors: Tadatsune Iida; Shinji Tanaka; Shigeo Okabe
• Keywords: Neocortex

Microglia regulate synapse stability and remodeling through multiple molecular pathways. Regulated spatial distribution of microglia within nervous tissues may affect dynamics. Here, we focused on the relationship between spine synapses in mouse neocortex found that distance microglial cell bodies (MCBs) spines is a critical parameter stability. The region close to MCBs contains processes with higher density more contacts. This also shows extensive exploration tissue space by processes. To test if relative positions are important for stability, simultaneously imaged vivo negative correlation spine-MCB Optical clearing methods enabled us record all large cortical volume indicated their mutually exclusive similar across layers. arrangement responsible repeated appearance domains along dendritic arborization. position was largely independent other cellular components. These results suggest generating repetitive synaptic instability dendrites, which operates independently glial