Dopamine dysregulation in Parkinson's disease flattens the pleasurable urge to move to musical rhythms

• DOI: 10.1111/ejn.16128
• Publication Date: 2023-09-19T11:14:43Z
• Authors: Victor Pando‐Naude; Tomas Edward Matt...; Andreas Højlund; Sebastian Jakobsen; Karen Østergaard; Erik Johnsen; Eduardo A. Garza‐...; Maria A. G. Witek; Virginia Penhune; Peter Vuust
• Keywords: predictive processes; harmony; Parkinson's disease; Dopamine; Brain; Parkinson Disease; 16. Peace & justice; rhythm; 03 medical and health sciences; 0302 clinical medicine; music-induced pleasure; basal ganglia; Auditory Perception; Humans; dopamine; Music

Abstract The pleasurable urge to move music (PLUMM) activates motor and reward areas of the brain is thought be driven by predictive processes. Dopamine in limbic networks implicated beat‐based timing music‐induced pleasure, suggesting a central role basal ganglia (BG) dopaminergic systems PLUMM. This study tested this hypothesis comparing PLUMM participants with Parkinson's disease (PD), age‐matched controls, young controls. Participants listened musical sequences varying rhythmic harmonic complexity (low, medium high), rated their experienced pleasure rhythm. In line previous results, healthy younger showed an inverted U‐shaped relationship between ratings, preference for rhythms, while controls similar, but weaker, response. Conversely, PD significantly flattened response both pleasure. Crucially, could not attributed differences rhythm discrimination did reflect overall decrease ratings. For complexity, negative linear pattern same U move. contrasts observed studies, that aging also influence affective responses complexity. Together, these results support dopamine within cortico‐striatal circuits processes form link perceptual processing patterns music.