Molecular interplay between phytoconstituents of Ficus Racemosa and neurodegenerative diseases

• DOI: 10.1111/ejn.16250
• Publication Date: 2024-01-13T07:55:05Z
• Authors: Anu Rani; Zia‐Ul‐Sabah; Fauzia Tabassum; Arun K. Sharma
• Keywords: 0303 health sciences; 03 medical and health sciences; Plant Extracts; Phytochemicals; Humans; Neurodegenerative Diseases; Ficus

AbstractNeurodegenerative diseases (NDs) are a significant global health concern, primarily affecting middle and older populations. Recently, there has been growing interest in herbal therapeutics as a potential approach to address diverse neuropathological conditions. Despite the widespread prevalence of NDs, limited phytochemical has been reported for their promising therapeutic potential with distinct underlying mechanisms. Additionally, the intricate molecular pathways influenced by herbal phytoconstituents, particularly in neurodegenerative disorders, are also not well documented. This report explores the phytoconstituents of Ficus racemosa (F. racemosa), an unfamiliar plant of the Moraceae family, for their potential interactions with pathological pathways of NDs. The influential phytoconstituents of F. racemosa, including polyphenols, glycosides, terpenoids, and furocoumarin, have been reported for targeting diverse pathological states. We proposed the most convincing molecular interplay between leading phytoconstituents and detrimental signalling cascades. However, extensive research is required to thoroughly understand the phytochemical persuaded intricate molecular pathway. The comprehensive evidence strongly suggests that F. racemosa and its natural compounds could be valuable in treating NDs. This points towards an exciting path for future research and the development of potential treatments based on a molecular level.