Early and late contingent negative variation (CNV) reflect different aspects of deficits in schizophrenia

• DOI: 10.1111/ejn.16340
• Publication Date: 2024-04-25T02:43:37Z
• Authors: Özge Akgül; Ezgi Fide; Fatih Özel; Köksal Alptekin; Emre Bora; Berna Binnur Akdede; Görsev Yener
• Keywords: Contingent negative variation

Abnormal reward processing and psychomotor slowing are well-known in schizophrenia (SZ). As a slow frontocentral potential, contingent negative variation (CNV) is associated with anticipatory attention, motivation motor planning. The present study aims to evaluate the early late amplitude latencies of CNV patients SZ compared healthy controls during task show its association clinical symptoms. We recruited 21 22 compare latency values Monetary Incentive Delay (MID) Task between groups. Patients' symptom severity, levels symptoms depressive were assessed. Clinical features further examined for their relation components. In conclusion, we found decreased amplitudes condition. They also displayed diminished shortened responses incentive cues, specifically at central location. Furthermore, exhibited significant correlation positive Both linked medication dosage behavioural outcomes MID task. revealed that exhibit different functions neurophysiology correspond various facets deficits observed patients. Our findings emphasized cortical potentials indicative deficient motivational processes as well impaired reaction preparation SZ. To gain deeper understanding cognitive impairments psychosis, future studies must effects phases.