Loss of cerebral white matter in primary Sjögren's syndrome: a controlled volumetric magnetic resonance imaging study

• DOI: 10.1111/ene.12486
• Publication Date: 2014-06-19T10:34:54Z
• Authors: M. B. Lauvsnes; M. K. Beyer; S. Appenzeller; O. J. Greve; E. Harboe; L. G. Gøransson; A. B. Tjensvoll; R. Omdal
• Keywords: Grey matter; Voxel-based morphometry

Background and purpose Although brain involvement is common in primary S jögren's syndrome ( pSS ), results from cerebral imaging studies are inconsistent. This study aimed to perform both voxel‐wise global volume analyses a nearly population‐based cohort explore whether the patients displayed any focal or diffuse differences compared with healthy subjects. Methods Global grey matter GM ) white WM volumes were measured 60 p SS age‐ gender‐matched Regression models constructed potential explanatory variables for volumes. In same groups, morphometric performed. Results of , had lower than subjects (540 ± 63 cm 3 vs. 564 56 P = 0.02), but no . Voxel‐wise localized areas between Conclusion Individuals have reduction loss indicates general deleterious effect on due itself.