All‐cause mortality following a cancer diagnosis amongst multiple sclerosis patients: a Swedish population‐based cohort study

• DOI: 10.1111/ene.12710
• Publication Date: 2015-04-22T09:09:25Z
• Authors: H. Roshanisefat; S. Bahmanyar; J. Hillert; T. Olsson; S. Montgomery
• Keywords: Standardized mortality ratio

A reduced cancer risk amongst patients with multiple sclerosis (MS) has been reported. Theoretically, this could represent a genuine reduction in or, alternatively, 'diagnostic neglect', where is undiagnosed when symptoms are misattributed to MS.Assess all-cause mortality following diagnosis MS compared cohort without MS.A of (n = 19,364) and the general population 192,519) were extracted from national Swedish registers 1969 2005. All-cause after was population. Poisson regression analysis conducted non-MS cohorts separately. The models adjusted for follow-up duration, year at entry, sex, region socioeconomic index. two combined differences assessed using interaction testing.The relative (and 95% confidence interval) (compared cancer) 3.06 (2.86-3.27; n 1768) those 5.73 (5.62-5.85; 24,965). This lower magnitude confirmed by multiplicative testing (P < 0.001).A consistent pattern range organ-specific types found. It suggests that diagnoses tend not be delayed diagnostic neglect unlikely account associated MS. may due disease-associated characteristics or exposures.