Uveitis and optic perineuritis in the context of myelin oligodendrocyte glycoprotein antibody seropositivity

• DOI: 10.1111/ene.13932
• Publication Date: 2019-02-12T19:48:11Z
• Authors: S. Ramanathan; C. Fraser; S. R. Curnow; M. Ghaly; R. J. Leventer; J. Lechner‐Scott; A. Henderson; S. Reddel; R. C. Dale; F. Brilot
• Keywords: Optic neuritis; Myelin oligodendrocyte glycoprotein

Background and purpose Antibodies to myelin oligodendrocyte glycoprotein (MOG) have been identified in both children adults with demyelination, a strong association bilateral or recurrent optic neuritis (ON). However, the full clinical spectrum of this newly described condition is unknown. We sought describe non‐ON inflammatory ophthalmological presentations such as uveitis perineuritis context MOG antibody seropositivity. Methods Using live cell‐based assay analysed by flow cytometry, we seropositive patients referred for testing Australasia between 2014 2017. four antibody‐positive present their detailed information case series. Results Three had either with, remote from, ON. One patient peripheral ulcerative keratitis. presentation, examination, investigation findings course these patients. Conclusions Recognition novel associations may expand antibody‐associated presentations. An expedited diagnosis guide management complex