Association between liver fibrosis and cognition in a nationally representative sample of older adults

• DOI: 10.1111/ene.14384
• Publication Date: 2020-06-05T21:09:49Z
• Authors: N. S. Parikh; S. Kumar; R. Rosenblatt; C. Zhao; D. E. Cohen; C. Iadecola; H. Kamel
• Keywords: Association (psychology); Sample (material)

Liver fibrosis, a common yet often subclinical manifestation of chronic liver disease, may have an unrecognized role in cognitive impairment. We evaluated the association between validated fibrosis index and measures among older adults.We examined performance participants aged 60 years US National Health Nutrition Examination Survey. was measured with Fibrosis-4 (FIB-4) score. The outcomes were on four standardized tests immediate delayed verbal learning, fluency, attention/concentration. used linear regression to evaluate FIB-4 score while adjusting for potential confounders. In sensitivity analyses, we this without known disease.Among 3217 adult participants, mean age 69 years, 54% women. Standard chemistries largely normal range. However, 5.0% [95% confidence interval (CI) 4.0-6.0] had based cut-off. adjusted models, higher scores associated worse recall (β -0.39; 95% CI -0.58, -0.21), language fluency -0.46; -0.72, attention/concentration -1.34; -2.25, -0.43), but not -0.10; -0.20, 0.01). Results similar when limiting study population clinical disease.Liver including be independent risk factor impairment adults.