Altered resting‐state functional connectivity between subregions in the thalamus and cortex in migraine without aura

Posterior cingulate
DOI: 10.1111/ene.14411 Publication Date: 2020-06-20T01:31:21Z
ABSTRACT
Background and purpose Migraine is a complex disabling neurological disorder, the exact mechanisms of which remain unclear. The thalamus considered to be hub central processing integration nociceptive information, as well modulation these processes. Methods A total 48 migraineurs without aura (MWoAs) during interictal phase age‐ sex‐matched healthy controls underwent resting‐state functional magnetic resonance imaging scans. We utilized masked independent component analysis seed‐based connectivity (FC) investigate whether MWoAs exhibited abnormal FC between subregions in cortex regions. Results showed significantly weaker anterior dorsal thalamic nucleus left precuneus. Additionally, reduced ventral posterior (VPN) precuneus, right inferior parietal lobule (R‐IPL) middle frontal gyrus. Furthermore, Z‐scores VPN R‐IPL were negatively correlated with pain intensity MWoAs. disease duration patients was R‐IPL. Conclusion These altered thalamocortical patterns may contribute multisensory abnormalities, deficits attention, cognitive evaluation modulation. Pain sensitivity are closely tied Remarkably, recurrent headache attacks might this maladaptive plasticity related intensity.
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