Integrating genetic and clinical data to predict impulse control disorders in Parkinson's disease

• DOI: 10.1111/ene.14590
• Publication Date: 2020-10-14T06:27:21Z
• Authors: S. Jesús; M. T. Periñán; C. Cortés; D. Buiza‐Rueda; D. Macías‐García; A. Adarmes; L. Muñoz‐Delgado; M. Á. Labrador‐Es...; C. Tejera‐Parrado; M. P. Gómez‐Garre; P. Mir
• Keywords: Male; Dopa decarboxylase gene; Dopamine; Impulse control disorders; Parkinson Disease; Middle Aged; Polymorphism, Single Nucleotide; 3. Good health; Disruptive, Impulse Control, and Conduct Disorders; 03 medical and health sciences; 0302 clinical medicine; Dopamine Agonists; Genetics; Parkinson’s disease; Humans; Female; DDC; Dopaminergic pathway genes; Aged

Impulse control disorders (ICDs) are frequent in Parkinson's disease (PD), with associated clinical and genetic risk factors. This study was aimed at analyzing the features background that underlie ICDs PD.We included 353 patients PD this (58.9% men, mean age 62.4 ± 10.58 years, onset 52.71 11.94 years). We used validated Questionnaire for Impulsive-Compulsive Disorders Disease screening. Motor, nonmotor, treatment-related were evaluated according to presence of ICDs. Twenty-one variants related dopaminergic, serotonergic, glutamatergic, opioid neurotransmitter systems assessed. Association studies between polymorphisms performed. The combination variables analyzed receiver operating characteristic curves assess predictability experiencing ICDs.Impulse appeared 25.1% cases. Patients younger presented a higher rate anxiety. Treatment dopamine agonists increased it dose dependent (P < 0.05). Genetic association showed DOPA decarboxylase gene (DDC), rs1451375, might modulate Plotting clinical-genetic model, 11% (area under curve = 0.80; z 3.22, P 0.001) when adding genotype data single nucleotide polymorphisms.Polymorphisms DDC act as markers PD. by factors features. It is therefore important patient's identify individuals