β‐Amyloid may accumulate in the human brain after focal bacterial infection: An 18F‐flutemetamol positron emission tomography study

• DOI: 10.1111/ene.14622
• Publication Date: 2020-11-01T03:27:07Z
• Authors: Ane Gretesdatter ...; Ebba Gløersen Müller; Eirin Udnæs; Solrun Sigurdardo...; Rune Raudeberg; James Patrick Con...; Mona‐Elisabeth Re...; Bjørnar Hassel; Daniel Dahlberg
• Keywords: Brain abscess; Amyloid (mycology); Cognitive Decline

Abstract Background and purpose β‐Amyloid formation has been suggested to form part of the brain's response bacterial infection. This hypothesis based on experimental animal studies autopsy in humans. We asked if β‐amyloid accumulates locally around a brain abscess living human patients. Furthermore, because patients may suffer from chronic cognitive symptoms after treatment, we also precipitates accumulation neocortex manner that could explain abscess‐related complaints. Methods In prospective study, investigated 17 (age 24–72 years) with 18 F‐flutemetamol positron emission tomography one occasion 1 10 months treatment visualize accumulation. Results uptake was reduced edematous tissue surrounded remains. On this background signal, three out showed distinctly increased immediately surrounding remains, suggesting β‐amyloid. These underwent significantly earlier neurosurgical ( p = 0.042), they had larger abscesses 0.027) than rest All suffered mental fatigue or some subjective symptom, such as attention difficulties memory problems, but none there an increase neocortical signal. Conclusions accumulate remains abscess.