Paraneoplastic or not? Sirtuin 2 in anti‐N‐methyl‐d‐aspartate receptor encephalitis

• DOI: 10.1111/ene.15987
• Publication Date: 2023-07-22T20:58:41Z
• Authors: Oskar Stevens‐Jones; Hana Mojzisova; Martin Elisak; Radu Constantinescu; Jitka Hanzalova; Markus Axelsson; David Krysl
• Keywords: SIRT2

Abstract Background and purpose N ‐methyl‐ d ‐aspartate receptor (NMDAR) leucine‐rich glioma‐inactivated protein 1 (LGI1) encephalitis are important types of autoimmune (AE) with significant morbidity. In this study, we used a proteomic approach in search novel clinically relevant biomarkers these encephalitides. Methods Swedish Czech tertiary neuroimmunology centers collaborated retrospective exploratory study. Fifty‐eight cerebrospinal fluid (CSF) samples 28 patients AE (14 definite NMDAR, 14 LGI1 encephalitis) 30 controls were included. CSF analyzed using proximity extension assay technology (Olink Target 96 Inflammation panel). For each sample, 92 proteins measured. Clinical variables retrospectively collected, correlations levels statistically analyzed. Results Patients differed significantly the following 18 biomarkers: TNFRSF9, TNFRSF12, TNFRSF14, TNFβ, TNFα, IL7, IL10, IL12B, IFNγ, CD5, CD6, CASP8, MMP1, CXCL8, CXCL10, CXCL11, IL20RA, sirtuin 2 (SIRT2). encephalitis, no useful association was found between clinical variables. NMDAR group, SIRT2, CD5 associated ovarian teratoma. true even for first patients' sample (SIRT2 without vs. tumor, mean ± SD = 2.2 0.29 2.88 0.48; p 0.007, 95% confidence interval −1.15 to −0.22; r statistic point‐biserial correlation (rpb) 0.66, 0.011). SIRT2 positively correlated age (rpb 0.39, 0.018) total hospital days ( 0.55, <0.001). Conclusions should be investigated as biomarker paraneoplastic etiology encephalitis.