Is the cingulate island sign a marker for early dementia conversion in Parkinson's disease?

• DOI: 10.1111/ene.16007
• Publication Date: 2023-07-28T16:34:10Z
• Authors: Seok Jong Chung; Su Hong Kim; Chan Wook Park; Hye Sun Lee; Yun Joong Kim; Phil Hyu Lee; Yong Jeong; Young H. Sohn
• Keywords: Putamen; Posterior cingulate

To investigate whether the cingulate island sign (CIS) ratio (i.e., of regional uptake in posterior cortex relative to precuneus and cuneus on cerebral perfusion scans) is associated with early dementia conversion Parkinson's disease (PD).We enrolled 226 patients newly diagnosed PD 48 healthy controls who underwent dual-phase 18 F-FP-CIT PET scans. Patients were classified into three groups according CIS early-phase images: a group or high ratios (PD-CIS; n = 96), inverse low (PD-iCIS; 40), consisting remaining normal (PD-nCIS; 90). We compared risk within 5-year time point between groups.There no significant differences age, sex, education, baseline cognitive function groups. The PD-CIS had higher Unified Disease Rating Scale (UPDRS) motor scores more severely decreased dopamine transporter availability putamen. PD-iCIS smaller hippocampal volume other did not differ from that PD-nCIS Meanwhile, than group.The results this study suggest CIS, rather relevant PD.