Tremor after solid organ transplantation: Results from the TransplantLines Biobank and Cohort Study

• DOI: 10.1111/ene.16412
• Publication Date: 2024-10-23T09:41:07Z
• Authors: A. Madelein M. va...; Niels L. Riemersma; Tim J. Knobbe; Daan Kremer; Svea Nolte; Danieke B. Plasme...; Antonio. W. Gomes...; Stephan J. L. Bakker; Gea Drost; Jan Willem J. Elting
• Keywords: Postural tremor

Abstract Background and purpose Tremor is a frequent complaint of solid organ transplant recipients. We report on the largest population investigated with clinical neurophysiological methods. Our aim to objectively establish tremor prevalence syndrome in Methods was measured heart, kidney, liver, lung recipients, using accelerometers during rest, postural, weight‐loaded conditions. The 95th percentile healthy kidney donors' amplitude used as cutoff determine presence frequency, frequency variability, effect loading were investigate enhanced physiological likely syndrome. Impact activities daily life assessed, correlations tacrolimus blood levels investigated. Results present 52% 246 typically postural positions. Mean 6.1 (±2.0) Hz; mean variability 2.6 (±1.8) Hz. A decrease upon found 83% patients tremor. Sixty‐five percent met formal criteria for Tremor‐related impairment 55% correlated (ρ = 0.23, p ≤ 0.001). In binominal regression analysis, independently associated ( 0.009). Conclusions More than half recipients experience that best fits This first objective study has established better understanding mechanisms large