Global, Regional, and National Burden of Early‐Onset Alzheimer's Disease and Other Dementias in Young Adults Aged 40–64 Years, 1990–2021: A Population‐Based Study

• DOI: 10.1111/ene.70116
• Publication Date: 2025-03-19T12:38:47Z
• Authors: Zenghui Zhang; Shaojie Han; Huimin Zhu; Qianyun Wang; Siyuan Cheng; Yuchen Han; Fengjuan Li; Jun Guo

ABSTRACT Background and Purpose Early‐onset Alzheimer's disease other dementias (EOAD) impose significant burdens on affected individuals their families. However, the global burden of EOAD has not been fully investigated. We aimed to assess global, regional, national using data from Global Burden Diseases, Injuries, Risk Factors (GBD) study 1990 2021. Methods Data for adults aged 40–64 were extracted within GBD 2021 framework. Primary outcomes included age‐standardized prevalence, incidence, mortality, disability‐adjusted life years (DALYs) EOAD, as well average annual percentage change (AAPC) across 21 regions 204 countries. Results In 2021, cases reached 7.75 million (95% uncertainty interval [UI] 5.82–10.08), up 3.67 UI 2.75–4.76) in 1990. The prevalence rate increased 341.2 per 100,000 255.89–442.79) 363.5 with an AAPC 0.26% ( p < 0.001). was higher women than men (4.28 million, 95% 3.24–5.56, vs. 3.46 2.57–4.52). associated 0.07 0.01–0.23) deaths 3.77 1.69–8.88) DALYs Additionally, 1.06 0.07–3.03) attributable smoking, elevated fasting plasma glucose, high body mass index. Conclusions number among more doubled Targeted strategies interventions are urgently needed address this growing public health issue.