Recurrent aphthous stomatitis and gene variability in selected interleukins: a case–control study

• DOI: 10.1111/eos.12577
• Publication Date: 2018-10-20T08:29:40Z
• Authors: Petra Borilova Li...; Julius Janos; Simona Slezakova; Jirina Bartova; Jitka Petanova; Pavel Kuklinek; Antonin Fassmann; Ladislav Dusek; Lydie Izakovicova...
• Keywords: Recurrent aphthous stomatitis; Interleukin 13

Genetic factors, especially those related to immune system functioning, have been intensively studied determine their role in the development of recurrent aphthous stomatitis (RAS). The aim present study was analyze gene variability interleukin ( IL ) 2 , IL4 (and its receptor α, IL4Rα IL10 and IL13 which were selected based on literature review and/or functional relevance, Czech patients with RAS healthy controls. In total, 252 subjects (178 controls 74 RAS) enrolled this case–control study, detailed anamnestic, clinical, laboratory data obtained. Nine polymorphisms genes encoding interleukins determined using PCR techniques. There no significant differences allele or genotype frequencies IL2 rs2069762/rs2069763, rs2243250/rs79071878, rs1801275, rs1800896, rs1800925, respectively, between RAS. minority alleles rs1800871 rs1800872, encode variants associated a statistically significantly higher risk RAS, as confirmed by results haplotype analyses. We suggest that may play an important population.