Frontal lobe seizures: From clinical semiology to localization

• DOI: 10.1111/epi.12490
• Publication Date: 2013-12-24T18:41:12Z
• Authors: Francesca Bonini; Aileen McGonigal; Agnès Trébuchon; Martine Gavaret; Fabrice Bartolomei; Bernard Giusiano; Patrick Chauvel
• Keywords: Stereoelectroencephalography; Frontal lobe; Semiology; Premotor cortex; Supplementary motor area

Frontal lobe seizures are difficult to characterize according semiologic and electrical features. We wished establish whether different subgroups can be identified these relate anatomic organization.We assessed all from 54 patients with frontal epilepsy that were explored stereoelectroencephalography (SEEG) during presurgical evaluation. Semiologic features concomitant intracerebral EEG changes documented quantified. These variables examined using Principal Component Analysis Cluster Analysis, correlated localization.Four main groups of features, specific patterns seizure localization. Group 1 was characterized clinically by elementary motor signs involved precentral premotor regions. 2 a combination nonintegrated gestural behavior, both prefrontal 3 integrated behavior distal stereotypies anterior lateral medial 4 fearful the paralimbic system (ventromedial cortex ± temporal structures). The organized along rostrocaudal axis, representing bands within spectrum rather than rigid categories. more organization, likely occurrence seizures. Distal associated most localizations, whereas proximal occurred in posterior regions.Meaningful categorization terms semiology is possible correlates organization keeping current hypotheses hierarchical organization. proposed electroclinical offers pointers as zone networks underlying production, thus aiding Furthermore, analysis ictal seizures, including stereotypies, leads deciphering cortico-subcortical produce such behaviors.