Spike wave location and density disturb sleep slow waves in patients with CSWS (continuous spike waves during sleep)

• DOI: 10.1111/epi.12576
• Publication Date: 2014-03-20T19:08:29Z
• Authors: Bigna K. Bölsterl...; Sara Fattinger; Salomé Kurth; Monique K. LeBour...; Maya Ringli; Thomas Bast; Hanne Critelli; Bernhard Schmitt; Reto Huber
• Keywords: Sleep

Summary Objective In CSWS (continuous spike waves during sleep) activation of slow wave sleep has been causally linked to neuropsychological deficits, but the pathophysiologic mechanisms are still unknown. healthy subjects, overnight decrease slope in NREM (non–rapid eye movement) brain recovery regain optimal cognitive performance. Here, we investigated whether electrophysiologic hallmark , sleep, is related an alteration slope, and if this location density waves. Methods a retrospective study, (0.5–2 Hz) first hour last (19 electroencephalography [ EEG ] electrodes) 14 patients with (3.1–13.5 years) was calculated. The “focus” determined as highest amplitude index ( SWI ). Results There no change “focus.” Instead, “nonfocal” regions, decreased significantly. This difference course resulted steeper compared electrodes sleep. Spike correlated impairment decrease: higher more hampered decrease. Significance Location physiologic slope. shown be closely function Such necessary for performance wakefulness. Therefore propose process by potential mechanism leading deficits . A PowerPoint slide summarizing article available download Supporting Information section here