Age‐dependent mesial temporal lobe lateralization in language fMRI

• DOI: 10.1111/epi.13258
• Publication Date: 2015-12-23T09:12:40Z
• Authors: Leigh N. Sepeta; Madison M. Berl; Marko Wilke; Xiaozhen You; Meera Mehta; Benjamin Xu; Sara Inati; Irene Dustin; Omar Khan; Alison Austermuehle; William H. Theodore; William D. Gaillard
• Keywords: Statistical parametric mapping

Summary Objective Functional magnetic resonance imaging ( fMRI ) activation of the mesial temporal lobe MTL may be important for epilepsy surgical planning. We examined and lateralization during language in children adults with focal epilepsy. Methods One hundred forty‐two controls patients left hemisphere (pediatric: epilepsy, n = 17, mean age 9.9 ± 2.0; controls, 48; 9.1 2.6; adult: 20, 26.7 5.8; 57, 26.2 7.5) underwent 3T using a task (auditory description decision task). Image processing analyses were conducted Statistical Parametric Mapping (SPM8); regions interest ROI s) included , Broca's area, Wernicke's area. assessed group individual activation, degree lateralization. Results Patients (pediatric adult) demonstrated . was lateralized adults, but less so (p's < 0.005). did not differ from either group. Stronger left‐lateralized related to older (p 0.02). Language (Broca's Wernicke's) predicted 19% variance 0.001), children. Significance used elicit activation. The developmental difference its association suggests shift function, increased across span. This help explain why have better memory outcomes following resection compared adults.