Temporal behavior of seizures and interictal bursts in prolonged intracranial recordings from epileptic canines

• DOI: 10.1111/epi.13591
• Publication Date: 2016-11-03T08:43:01Z
• Authors: Hoameng Ung; Kathryn A. Davis; Drausin Wulsin; Joost Wagenaar; Emily Fox; John J. McDonnell; Ned Patterson; Charles H. Vite; Gregory Worrell; Brian Litt
• Keywords: Electrocorticography

Summary Objective Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The behavior of seizures and interictal bursts that sometimes initiate them unknown. We investigate variability these electrographic patterns over an extended period time using intracranial canine epilepsy. Methods Continuous, yearlong electroencephalography (i EEG ) from four dogs with naturally occurring epilepsy were analyzed for bursts. Following automated detection clinician verification seizures, temporal trends burst count, burst–burst similarities determined. One dog developed status epilepticus, which also investigated. Results Multiple types, determined by onset channels, observed each dog, significant variation between types. first 14 days invasive recording, analogous to average duration clinical humans, did not capture entirety Seizures typically occurred clusters, isolated rare. count dynamics form distinct groups do stabilize until several weeks after implantation. Significance There electrode implantation requires reach steady state. These findings, comparable those reported humans implanted NeuroPace Responsive Neurostimulator System (RNS) device, suggest transient network changes following may need be taken into account when interpreting or analyzing i during evaluation surgery. Chronic, ambulatory better suited accurately map epileptic networks appropriate individuals.