Individualized prediction of seizure relapse and outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery

• DOI: 10.1111/epi.14020
• Publication Date: 2018-02-15T11:26:57Z
• Authors: Herm J. Lamberink; Kim Boshuisen; Willem M. Otte; Karin Geleijns; Kees P. J. Braun
• Keywords: Concordance; Antiepileptic drug; Nomogram

Summary The objective of this study was to create a clinically useful tool for individualized prediction seizure outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery. We used data from the European retrospective TimeToStop study, which included 766 children 15 centers, perform proportional hazard regression analysis. 2 outcome measures were recurrence and freedom in last year follow‐up. Prognostic factors identified through systematic review literature. strongest predictors each selected backward selection, nomograms created. final models 3 5 per model. Discrimination terms adjusted concordance statistic 0.68 (95% confidence interval [ CI ] 0.67‐0.69) predicting 0.73 0.72‐0.75) eventual freedom. An online is provided on www.epilepsypredictiontools.info/ttswithdrawal . presented can improve counseling patients parents regarding postoperative policies, by estimating risks outcome.