The Akkermansia muciniphila is a gut microbiota signature in psoriasis

• DOI: 10.1111/exd.13463
• Publication Date: 2017-11-11T12:38:41Z
• Authors: LiRong Tan; Shuang Zhao; Wu Zhu; Lisha Wu; Jie Li; MinXue Shen; Li Lei; Xiang Chen; Cong Peng
• Keywords: Akkermansia muciniphila; Pathogenesis; Interleukin-23; Immune Dysregulation

Psoriasis is an immune-mediated chronic inflammatory skin disease. Although its pathogenesis not fully understood, Th17 cells and the cytokines they produce, such as IL-17, IL-22 IL-23, play critical roles in of psoriasis. Evidence has demonstrated that psoriasis some common features, including immune responses (due to cells) cytokine profiles, with systematic diseases bowel (IBDs) obesity. Recently, studies have gut microbiota plays a crucial role host homoeostasis response, particular cells, but remains unclear. To study relationship between psoriasis, we analysed profiles using 16S rDNA sequencing platform, found abundance Akkermansia muciniphila was significantly reduced patients A. believed important function IBD obesity; therefore, muciniphila, which indicator health status, may be key node for well Taken together, our identified signature are altered provides novel angle understanding