Genome‐wide association study of psoriasis in an Egyptian population

• DOI: 10.1111/exd.13926
• Publication Date: 2019-03-28T16:55:03Z
• Authors: Yosra Bejaoui; Mareike Witte; Mohamed Abdelhady; Mohammad Eldarouti; Nermeen M. A. Abd...; Ashraf Antar Elgh...; Ziyad Tawhid; Mohammad Ali Gaba...; Hauke Busch; Matthias Munz; Mareike Wendorff; Eva Ellinghaus; Andre Franke; Saleh M. Ibrahim
• Keywords: Genome-wide Association Study; Genetic Association; SNP; Candidate gene; Concordance

Abstract Psoriasis is a chronic inflammatory disorder of the skin, with genetic factors reportedly involved in disease pathogenesis. Numerous studies reported psoriasis candidate genes. However, these tend to involve mostly European and Asian populations. Here, we report first genome‐wide association study ( GWAS ) an Egyptian population, identifying susceptibility variants for using two‐stage case‐control design. In discovery stage, carried out analysis Infinium ® Global Screening Array‐24 v1.0, on 253 cases 449 control samples descent. second replication 26 single‐nucleotide polymorphisms SNP s) were selected additional 321 controls. concordance findings from previous other populations, found significant between MHC locus at rs12199223 P comb = 6.57 × 10 −18 rs1265181 1.03 −10 ). Additionally, identified novel locus, 4q32.1 (rs12650590, 4.49 −08 vicinity gene GUCY 1A3, multiple suggestive associations, example rs10832027 com b 7.28 −06 rs3770019 1.02 −05 This proposes existence important interethnic differences susceptibility. Further are necessary elucidate downstream pathways new loci.