Characterization of circadian human facial surface lipid composition

• DOI: 10.1111/exd.13933
• Publication Date: 2019-04-11T23:41:03Z
• Authors: Yan Jia; Mingyue Zhou; Hong Huang; Yao Gan; Manli Yang; Ruiheng Ding
• Keywords: Lipid Profile

Abstract Background The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at level; however, few studies molecular level reported. Additionally, there no study on lipidomic profile variations surface lipid (SSL), which could potentially explain status. Objectives SSL healthy young women was analysed to assess and status during cycle. Methods Ultra performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry multivariate data analysis were performed variations. Results showed significant differences with rhythm. Multivariate indicated glycerolipids lipids majorly affected by profile, both average chain length content free fatty acids (FFAs) higher 20:00 than 08:00. Conclusions significantly varied respect rhythm‐altered triacylglycerol level, FFA resulted function, including transepidermal water loss alteration pH variation.