Increased angiogenesis and migration of dermal microvascular endothelial cells from patients with psoriasis

• DOI: 10.1111/exd.14329
• Publication Date: 2021-03-22T17:12:02Z
• Authors: Jiao Li; Hui Hou; Ling Zhou; Juanjuan Wang; Jiannan Liang; Junqin Li; Ruixia Hou; Xuping Niu; Guohua Yin; Xinhua Li; Kaiming Zhang
• Keywords: Adult; Male; Neovascularization, Pathologic; Endothelial Cells; Middle Aged; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Cell Movement; Microvessels; Humans; Psoriasis; Female; Cell Proliferation

Abstract Psoriasis displays both increased angiogenesis and microvascular dilation in the skin, while human dermal endothelial cells (HDMECs) are involved dilation. Whether functions of HDMECs altered psoriatic skin versus healthy remain unknown. Here, we isolated from 10 patients with psoriasis subjects compared angiogenesis, proliferation, migration cell metabolism between normal HDMECs. We found that morphology primary was comparable After passage, displayed larger size wider intercellular space. In addition to DiI‐Ac‐LDL (DiI‐labelled acetylated low‐density lipoprotein) uptake, expression levels CD31, vWF (von Willebrand factor) LYVE‐1 were However, exhibited tube formation (numbers nodes meshes, p < 0.05) migrated cells, 0.001) reductions proliferation (growth rates, energy (oxygen consumption rate extracellular acidification rate, Therefore, display an decreased metabolic activity, suggesting a pathogenic role psoriasis.