Increased angiogenesis and migration of dermal microvascular endothelial cells from patients with psoriasis

Adult Male Neovascularization, Pathologic Endothelial Cells Middle Aged Young Adult 03 medical and health sciences 0302 clinical medicine Cell Movement Microvessels Humans Psoriasis Female Cell Proliferation
DOI: 10.1111/exd.14329 Publication Date: 2021-03-22T17:12:02Z
ABSTRACT
Abstract Psoriasis displays both increased angiogenesis and microvascular dilation in the skin, while human dermal endothelial cells (HDMECs) are involved dilation. Whether functions of HDMECs altered psoriatic skin versus healthy remain unknown. Here, we isolated from 10 patients with psoriasis subjects compared angiogenesis, proliferation, migration cell metabolism between normal HDMECs. We found that morphology primary was comparable After passage, displayed larger size wider intercellular space. In addition to DiI‐Ac‐LDL (DiI‐labelled acetylated low‐density lipoprotein) uptake, expression levels CD31, vWF (von Willebrand factor) LYVE‐1 were However, exhibited tube formation (numbers nodes meshes, p < 0.05) migrated cells, 0.001) reductions proliferation (growth rates, energy (oxygen consumption rate extracellular acidification rate, Therefore, display an decreased metabolic activity, suggesting a pathogenic role psoriasis.
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