Strengthening the Skin Barrier by Using a Late Cornified Envelope 6A‐Derived Biomimetic Peptide

• DOI: 10.1111/exd.15191
• Publication Date: 2024-10-14T05:44:05Z
• Authors: Mikaël Pancarte; Julie Leignadier; Séverine Courrech; Guy Serre; Joan Attia; Nathalie Jonca
• Keywords: Human skin; Ex vivo; Barrier function

ABSTRACT Changes in the expression of cornified envelope (CE) components are a hallmark numerous pathological skin conditions and aging, underlying importance this stratum corneum structure homeostasis epidermal barrier. We performed detailed characterisation LCE6A, member Late Cornified Envelope protein family. Immunohistochemical immunoblot experiments confirmed that LCE6A is expressed late during differentiation. Crosslinking assays recombinant either situ on human sections or vitro demonstrated indeed substrate transglutaminases crosslinked to CEs. LCE6A‐derived peptides containing glutamine‐lysine sequence retained these properties full‐length reinforced mechanical resistance CE submitted sonication. designed P26, biomimetic peptide similarly vitro, evaluated its protective ex vivo, explants, two double blind vehicle‐controlled clinical trials. P26 was able protect from barrier disruption, limit damage resulting defective barrier, could improve signs aging such as loss firmness increased roughness. Hence, our component enabled us develop peptide, biologically active with new original mode action be great interest cosmetic ingredient pharmacologic agent.