Naphazoline and oxymetazoline are superior to epinephrine in enhancing the cutaneous analgesia of lidocaine in rats

• DOI: 10.1111/fcp.12853
• Publication Date: 2022-11-17T17:03:21Z
• Authors: An‐Kuo Chou; Chong‐Chi Chiu; Guan‐Cheng Zhu; Jhi‐Joung Wang; Yu‐Wen Chen; Ching‐Hsia Hung
• Keywords: Oxymetazoline; ED50; Adrenergic agonist

This study observed the cutaneous analgesic effect of adrenergic agonists when combined with lidocaine. We aimed at usefulness four and epinephrine as analgesics or tools to prolong local anesthetics using a model trunci muscle reflex (pinprick pain) in rats. showed that subcutaneous epinephrine, well anesthetic bupivacaine lidocaine, developed concentration-dependent analgesia. The rank order efficacy different compounds (ED50 ; median effective dose) was [0.013 (0.012-0.014) μmol] > oxymetazoline [0.25 (0.22-0.28) naphazoline [0.42 (0.34-0.53) = [0.43 (0.37-0.50) xylometazoline [1.34 (1.25-1.45) lidocaine [5.86 (5.11-6.72) tetrahydrozoline [6.76 (6.21-7.36) μmol]. duration full recovery caused by tetrahydrozoline, oxymetazoline, greater (P < 0.01) than induced via bupivacaine, equianesthetic doses (ED25 , ED50 ED75 ). Co-administration ) enhanced effect. induce analgesia themselves, such an has longer anesthetics. agonist enhances effect, plus (or oxymetazoline) is epinephrine.