2‐Deoxy‐D‐glucose has distinct and cell line‐specific effects on the survival of different cancer cells upon antitumor drug treatment

• DOI: 10.1111/febs.14687
• Publication Date: 2018-10-30T15:24:47Z
• Authors: Polina Maximchik; Alibek Abdrakhmanov; Evgeniya Inozemtseva; Pyotr A. Tyurin‐K...; Boris Zhivotovsky; Vladimir Gogvadze
• Keywords: 0301 basic medicine; Antimetabolites; Antineoplastic Agents; Apoptosis; Deoxyglucose; Endoplasmic Reticulum Stress; Mitochondria; 3. Good health; Neuroblastoma; 03 medical and health sciences; Colonic Neoplasms; Autophagy; Tumor Cells, Cultured; Humans; Cell Lineage; Cisplatin; Endoplasmic Reticulum Chaperone BiP; Cell Proliferation

The dependence of tumors on glycolysis for ATP generation offers a rationale therapeutic strategies aimed at selective inhibition the glycolytic pathway. Analysis tumor cell responses to anticancer drugs revealed that by 2‐deoxy‐D‐glucose (2‐ DG ) generally augmented apoptotic response; however, in HCT 116 human colon carcinoma cells, apoptosis was suppressed. A comparison neuroblastoma SK ‐N‐ BE (2) and cells revealed, contrast 116, 2‐ alone able induce death. In decrease levels upon treatment with more prominent because mitochondria compensated loss caused suppression. both lines triggered endoplasmic reticulum ( ER stress, assessed accumulation marker protein GRP 78/BiP. Suppression stress mannose attenuated ‐induced response implying these is consequence induction. stimulated autophagy, lipidated form LC 3. inhibitor autophagy reversed ‐mediated suppression cisplatin‐induced apoptosis. When suppressed bafilomycin, decreased. At same time, stimulation Thus, successful conventionally used should be combined targeting metabolic pathways involved regulation apoptosis, cellular bioenergetics.