Lactate protects neurons and astrocytes against ischemic injury by modulating Ca2+ homeostasis and inflammatory response

• DOI: 10.1111/febs.17051
• Publication Date: 2024-01-16T08:54:35Z
• Authors: Valentina A. Babenko; Elena G. Varlamova; Aleena A. Saidova; Egor A. Turovsky; Egor Y. Plotnikov
• Keywords: Proinflammatory cytokine; Homeostasis; Neuroglia

Lactate is now considered an additional fuel or signaling molecule in the brain. In this study, using oxygen-glucose deprivation (OGD) model, we found that treatment with lactate inhibited global increase intracellular calcium ion concentration ([Ca