Borderline personality disorder and childhood maltreatment: a genome‐wide methylation analysis

• DOI: 10.1111/gbb.12197
• Publication Date: 2015-01-22T09:39:25Z
• Authors: J. Prados; L. Stenz; P. Courtet; P. Prada; R. Nicastro; W. Adouan; S. Guillaume; E. Olié; J.‐M. Aubry; A. Dayer; N. Perroud
• Keywords: Adult; Genetic Markers; Male; [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health; [SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior; personality disorder; info:eu-repo/classification/ddc/616.89; ddc:616.89; 03 medical and health sciences; 0302 clinical medicine; Borderline Personality Disorder; Humans; genetics; Child Abuse; Child; miRNA; Psychiatric Status Rating Scales; Depressive Disorder, Major; [SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior; Epigenetic; info:eu-repo/classification/ddc/616.8; DNA Methylation; 3. Good health; ddc:616.8; life events; [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health; Female; Genome-Wide Association Study

Early life adversity plays a critical role in the emergence of borderline personality disorder ( BPD ) and this could occur through epigenetic programming. In perspective, we aimed to determine whether childhood maltreatment durably modify processes by means whole‐genome methylation scan subjects. Using Illumina Infinium® HumanMethylation450 BeadChip , global status DNA extracted from peripheral blood leucocytes was correlated severity 96 subjects suffering high level child 93 major depressive MDD reporting low rate maltreatment. Several CpGs within or near following genes IL17RA miR124‐3 KCNQ2 EFNB1 OCA2 MFAP2 RPH3AL WDR60 CST9L EP400 A2ML1 NT5DC2 FAM163A SPSB2 were found be differently methylated, either compared with relation A highly relevant biological result observed for cg04927004 close that significantly associated codes microRNA miRNA targeting several previously such as NR3C1 . Our results highlight potentially important played miRNAs etiology neuropsychiatric disorders usefulness using methylome‐wide association studies uncover candidate genes. Moreover, they offer new understanding impact maltreatments on leading diseases may ultimately identification biomarkers.