Comprehensive behavioral study and proteomic analyses of CRMP2‐deficient mice

• DOI: 10.1111/gtc.12403
• Publication Date: 2016-09-01T10:29:49Z
• Authors: Haruko Nakamura; Naoya Yamashita; Ayuko Kimura; Yayoi Kimura; Hisashi Hirano; Hiroko Makihara; Yuko Kawamoto; Aoi Jitsuki‐Takah...; Kumiko Yonezaki; Kenkichi Takase; Tomoyuki Miyazaki; Fumio Nakamura; Fumiaki Tanaka; Yoshio Goshima
• Keywords: Methamphetamine

Collapsin response mediator protein 2 (CRMP2) plays a key role in axon guidance, dendritic morphogenesis and cell polarization. CRMP2 is implicated various neurological psychiatric disorders. However, vivo functions of remain unknown. We generated gene-deficient (crmp2-/- ) mice examined their behavioral phenotypes. During 24-h home cage monitoring, the activity level during dark phase crmp2-/- was significantly higher than that wild-type (WT) mice. Moreover, time open arm an elevated plus maze longer for WT The duration social interaction shorter Crmp2-/- also showed mild impaired contextual learning. then methamphetamine-induced change increased ambulatory serotonin release. altered expression proteins involved GABAergic synapse, glutamatergic synapse neurotrophin signaling pathways. In addition, SNAP25, RAB18, FABP5, ARF5 LDHA, which are related genes to schizophrenia methamphetamine sensitization, decreased Our study implies dysregulation may be pathophysiology neuropsychiatric