USPIO‐related T1 and T2 mapping MRI of cartilage in a rabbit model of blood‐induced arthritis: a pilot study

• DOI: 10.1111/hae.12601
• Publication Date: 2014-12-29T12:14:12Z
• Authors: A. Amirabadi; L. Vidarsson; E. Miller; M. S. Sussman; K. Patil; H. Gahunia; S. A. F. Peel; A. Zhong; R. Weiss; G. Detzler; H. L. M. Cheng; R. Moineddin; A. S. Doria
• Keywords: Rabbit (cipher)

Summary Ultrasmall paramagnetic iron oxide ( USPIO )‐enhanced MRI is promising for evaluating inflammation. The aims of this study were to investigate the effect on cartilage T1 and T2 mapping, evaluate a proposed rapid vs. conventional map method imaging in blood‐induced arthritis model. Knees nine arthritic (induction by intra‐articular autologous blood injection) six control rabbits imaged over time (baseline, weeks 1, 5, 10) 1.5T . All had (35–75 μmol Fe/kg)‐enhanced at each point. (conventional rapid) maps signal‐to‐noise ratios SNR ) obtained pre‐ post‐ administration. Cartilage biochemistry histology compared with Excellent correlations noted between values histologic scores week 10 (medial, r = 0.93 , P 0.0007; lateral, 0.87 0.005) group, but not histology. Marginally significant differences observed 5 0.06 (P 0.02 only administration high doses group using method. No any points. short‐ TR protocols provided similar [(decreased trend)] > 0.05). Concomitant use mapping would impair identification interval changes maps. Rapid provides results method, its validation warrants further investigation.