Incidence of von Willebrand disease in Denmark, 1995‐2016: A cohort study

• DOI: 10.1111/hae.14257
• Publication Date: 2021-02-08T19:09:15Z
• Authors: Anne Sofie Dam La...; Thomas Bøjer Rasm...; Gretchen R. Chiu; Emily S. Brouwer; Lone Hvitfeldt Po...; Ellen Margrethe M...
• Keywords: von Willebrand Disease; Danish

Information about temporal development of von Willebrand disease (VWD) incidence at a population level is scarce. To our knowledge, no study has described the VWD level.To estimate overall and annual rates hospital diagnosed in Denmark between 1995 2016 as well frequency treated bleeding episodes before after diagnosis.A registry-based cohort that included all Danish patients with first diagnosis Denmark, identified National Patient Registry through 1995-2016.We 1,035 VWD. The rate 1995-2016 was 8.6 (95% CI: 8.1-9.2). age-standardized per 100 000 person-years varied 4.1 2.4-5.9) 1998 16.7 13.1-20.3) 2005. A prominent peak appeared from 2002 to 2008. One five years diagnosis, 6% 11.5% had least one episode. corresponding percentages were 7.9% 13.4%.These results are population-based estimates incidence. may be underestimated because asymptomatic individuals not diagnosed. observed 2002-2008 explained by increased medical attention, leading more being diagnosed, rather than an actual increase However, overall, we systematic changes over period.