Generalized Pain Sensitization and Endogenous Oxytocin in Individuals With Symptoms of Migraine: A Cross‐Sectional Study

• DOI: 10.1111/head.13213
• Publication Date: 2017-11-02T05:26:55Z
• Authors: Dokyoung S. You; Rachel Haney; Sergiu Albu; Mary W. Meagher
• Keywords: Allodynia

The current study examined pain and neurogenic inflammation responses to topical capsaicin during the interictal period (between headache) their relationship with plasma oxytocin in individuals migraine.Individuals migraine can experience generalized (extracephalic) hyperalgesia, which persist even between headache attacks. Elevated levels of cerebrospinal fluid have been observed attacks, being positively associated intensity symptoms. However, whether plays a role mechanisms sensitization has not studied yet. Understanding migraineurs' phenotype endogenous might help identify who would benefit from intranasal treatment.Thirty-two subjects 26 healthy controls underwent testing. compared capsaicin-induced pain, central (areas secondary mechanical allodynia hyperalgesia), (capsaicin-induced flare) on nondominant volar forearm migraineurs controls. Additionally, we symptoms, experimental affect.The results indicated significant group effect (P = .019): Migraineurs reported greater unpleasantness (M 1.2, SD 1.4) 0-10 scale showed larger areas flare (LnM 2.8, 0.4) than 0.5, 0.8; LnM 2.6, 0.4; ps < .032). In subgroup analysis, enhanced was found chronic .007), but episodic (Ps > .200), migraineurs. were elevated accounted for 18% difference unpleasantness. Within migraineurs, negatively psychological distress .030). period, sensitivity extracephalic regions unrelated symptom parameters .074). Lastly, no hyperalgesia >.298).The revealed that exhibit periods. addition, especially those migraine, had slightly controls, affective component pain. Therefore, treatment targeting may reduce migraine. Furthermore, increases be compensatory mechanism decrease therapeutic effects by reducing distress.