Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance

• DOI: 10.1111/hel.12503
• Publication Date: 2018-06-20T14:45:39Z
• Authors: Kosuke Sakitani; Toshihiro Nishizawa; Masahide Arita; Shuntaro Yoshida; Yosuke Kataoka; Daisuke Ohki; Hiroharu Yamashita; Yoshihiro Isomura; Akira Toyoshima; Hidenobu Watanabe; Toshiro Iizuka; Yutaka Saito; Junko Fujisaki; Naohisa Yahagi; Kazuhiko Koike; Osamu Toyoshima
• Keywords: Adult; Aged, 80 and over; Male; Helicobacter pylori; Original Articles; Kaplan-Meier Estimate; Middle Aged; Anti-Bacterial Agents; Helicobacter Infections; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Stomach Neoplasms; Gastroscopy; Humans; Female; Early Detection of Cancer; Aged; Follow-Up Studies; Retrospective Studies

AbstractBackgroundHelicobacter pylori eradication therapy is commonly performed to reduce the incidence of gastric cancer. However, gastric cancer is occasionally discovered even after successful eradication therapy. Therefore, we examined the prognosis of gastric cancer patients, diagnosed after successful H. pylori eradication therapy.Materials and MethodsAll‐cause death rates and gastric cancer‐specific death rates in gastric cancer patients who received successful H. pylori eradication treatment was tracked and compared to rates in patients who did not receive successful eradication therapy.ResultsIn total, 160 gastric cancer patients were followed‐up for up to 11.7 years (mean 3.5 years). Among them, 53 gastric cancer patients received successful H. pylori eradication therapy prior to gastric cancer diagnosis. During the follow‐up period, 11 all‐cause deaths occurred. In the successful eradication group, the proportion of patients with cancer stage I was higher. The proportions of patients who received curative endoscopic therapy and endoscopic examination in the 2 years prior to gastric cancer diagnosis were also higher in the successful eradication group. Kaplan–Meier analysis of all‐cause death and gastric cancer‐specific death revealed a lower death rate in patients in the successful eradication group (P = .0139, and P = .0396, respectively, log‐rank test). The multivariate analysis showed that endoscopy within 2 years before cancer diagnosis is associated with stage I cancer.ConclusionsPossible early discovery of gastric cancer after H. pylori eradication due to regular endoscopic surveillance may contribute to better prognosis of patients with gastric cancer.