Helicobacter pylori infection alters gastric and tongue coating microbial communities

• DOI: 10.1111/hel.12567
• Publication Date: 2019-02-08T06:56:06Z
• Authors: Yubin Zhao; Xuefeng Gao; Jiaxuan Guo; Dongbao Yu; Ying Xiao; Huijie Wang; Yuchan Li
• Keywords: CagA

Abstract Objective Infection with Helicobacter pylori ( H ), especially cytotoxin‐associated gene A‐positive (CagA+) strains, has been associated various gastrointestinal and extragastric diseases. The aim of this study was to characterize ‐induced alterations in the gastric tongue coating microbiota evaluate their potential impacts on human health. Design mucosa specimens were collected from 80 patients chronic gastritis, profiles generated by 16S rRNA sequencing. Samples grouped as negative (n = 32), CagA‐negative infection 13), CagA‐positive (n=35). comparison bacterial relative abundance made using a generalized linear model. Functional profiling microbial communities predicted PICRUSt BugBase. Microbial correlation networks produced utilizing SparCC method. Results Significant found +/CagA+ samples, represented decrease diversity, reduced Roseburia , increased abundances Haemophilus genera. At community level, functions involved biofilm forming, mobile element content, facultative anaerobiosis significantly decreased microbiome + subjects. presence CagA linked an proportion Gram‐negative bacteria stomach, thereby contributing upregulation lipopolysaccharide (LPS) biosynthesis. number interactions greatly both subject, cooperative dominated microbiome. Conclusions strains possessing may increase risk diseases, upregulating LPS biosynthesis stomach weakening defense oral against microorganisms pathogenic potential.