Evaluation of the effects of a proton pump inhibitor on Helicobacter pylori stool antigen testing

• DOI: 10.1111/hel.12961
• Publication Date: 2023-02-25T02:48:25Z
• Authors: Yusaku Kajihara; Tadashi Shimoyama; Ichiro Mizuki
• Keywords: Lansoprazole; Urea breath test; Rapid urease test

Some patients find it difficult to discontinue proton pump inhibitors (PPIs). Unlike the 13 C-urea breath test (UBT), stool antigen (SAT), particularly when domestically produced kits are used, may be less likely yield false-negative results.This prospective study included a convenience series of 35 healthy Japanese subjects. Based on statistical calculation, acceptable numbers subjects were considered at least 21 and 11 with without Helicobacter pylori (H. pylori) infection, respectively. The H. infection was determined using UBT or rapid urease test. SATs performed three novel (the immunochromatography tests Quick Navi™-H. [Navi™] Chaser® [Chaser®], bioluminescent enzyme immunoassay BLEIA® 'EIKEN' Antigen [BLEIA®]) before after oral PPI administration (30 mg lansoprazole once daily for 14 days). For each kit, sensitivities specificities calculated compared administration. Furthermore, cutoff index (COI) values in pylori-infected subjects.H. detected 68.6% (24/35) versus as follows: 79.2% (19/24) 100.0% (11/11) 75.0% (18/24) Navi™, respectively (p = 1); 87.5% (21/24) Chaser®, .371); (24/24) 95.8% (23/24) BLEIA®, 1). median COI 1389.0 3207.25, .0839).In specimens, antigenicity is maintained even during use. SAT recommended because its extremely high sensitivity.