Y‐box binding protein 1 is correlated with lymph node metastasis in intestinal‐type gastric cancer

• DOI: 10.1111/his.12570
• Publication Date: 2014-10-01T10:02:45Z
• Authors: TianTian Guo; YingNan Yu; George Wai‐Cheong...; Gyeong Hun Baeg; Aye Aye Thike; Tony Kiat‐Hon Lim; Puay Hoon Tan; Ken Matsumoto; Boon Huat Bay
• Keywords: Tissue microarray

Aims Y‐box binding protein‐1 ( YB ‐1) is known to modulate gene transcription and protein translation, as well cellular response drug treatment. The aim of this study correlate ‐1 expression levels with clinicopathological parameters in intestinal‐type gastric cancer tissue samples (as categorized by the Lauren classification) substantiate findings vitro experimentation. Methods results Paraffin‐embedded from 167 patients were used for construction microarrays TMA s). slides immunostained immunoreactivity score was based on weighted average intensity score. Univariate analysis revealed that immunohistochemical correlated significantly lymph node status P = 0.054, borderline significance) perforation 0.043). also found be an independent predictor spread multivariate analysis. Furthermore, si RNA ‐mediated knockdown MKN 7 cells (which originate tissue) inhibited cell migration 0.0002) invasion 0.0129) significantly. Conclusion associated a potential prognostic biomarker subtype cancer.