Evaluating the prognostic potential of the Ki67 proliferation index and tumour‐infiltrating lymphocytes in olfactory neuroblastoma

• DOI: 10.1111/his.13954
• Publication Date: 2019-07-15T17:35:04Z
• Authors: Marion Classe; Alice Burgess; Sophie El Zein; Michel Wassef; Philippe Herman; Geoffrey Mortuaire; Xavier Leroy; Gabriel G Malouf; Benjamin Verillaud
• Keywords: Proliferation index; Grading (engineering)

Olfactory neuroblastomas (ONBs) are rare malignant tumours that arise in the nasal vault. To date, Hyams grade remains only widely used histological grading system. However, it is based on morphological criteria, and has not been updated since 1988. The objective of this study was to explore prognostic potential Ki67 proliferation index (PI) tumour-infiltrating lymphocytes (TILs) ONB.A retrospective conducted a bicentric series 45 cases. PI determined by counting at least 1000 nuclei whole slides. TILs were evaluated with CD20, CD4 CD8 immunohistochemical markers In series, grades I, II, III IV accounted for 13.4%, 44.4%, 20% 22.2% all cases, respectively. ranged from 1 93; significantly higher III-IV ONBs than I-II (P < 0.0001). A ≥25 associated poorer survival = 0.02). present both stromal intratumoral compartments, but located predominantly component tumour. numbers CD8+ cells/mm2 CD4+ greater high-grade low-grade 0.0015 P 0.043, respectively). T B survival, CD4/CD8 ratio >2 shorter 0.04).Our findings suggest could be as markers, alternative grade.