Clinicopathological and molecular features of indolent natural killer‐cell lymphoproliferative disorder of the gastrointestinal tract

• DOI: 10.1111/his.14850
• Publication Date: 2022-12-10T04:14:11Z
• Authors: Hongmei Yi; Anqi Li; Binshen Ouyang; Qian Da; Lei Dong; Yingting Liu; Haimin Xu; Xiaoyun Zhang; Wei Zhang; Xiaofen Jin; Yijin Gu; Yan Wang; Zebing Liu; Chaofu Wang
• Keywords: Gastrointestinal Tract; Killer Cells, Natural; 03 medical and health sciences; 0302 clinical medicine; Lymphoma; Humans; Natural Killer T-Cells; Lymphoproliferative Disorders; 3. Good health

Indolent natural killer (NK) cell lymphoproliferative disorder of the gastrointestinal (GI) tract (iNKLPD) is a rare, recently recognised neoplasm. Most reported tumours are confined to GI tract, while small subset harbour JAK3 mutations. We collected four cases iNKLPD with goal adding additional information current knowledge this disease regarding clinicopathological, immunohistochemical and molecular features.Similar features including medium- large-sized lymphoid cells variable amounts pale or slightly eosinophilic cytoplasm, no evidence EBER, TCR rearrangement were found in cases. K563_C565del mutation was one three that subjected targeted next-generation sequencing. Unique findings our study include encountered for first time nasopharynx, where lesions could be inadvertently diagnosed as extranodal NK/T lymphoma, located gallbladder extended deeply into muscular adventitial layers. Exceptional CD8-positive expression observed iNKLPD. In addition, positive staining phospho-STAT5, phospho-STAT3 phospho-p38 None patients received therapy but all had benign clinical outcome during follow-up 20-99 months.We present iNKLPDs clinical, similar cases, well some unusual characters, which expand on disease, further support neoplastic nature iNKLPDs.