Factors associated with obesity in the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) cohort: an observational cross‐sectional analysis

• DOI: 10.1111/hiv.12857
• Publication Date: 2020-04-20T23:36:25Z
• Authors: S Savinelli; D De Francesco; ER Feeney; D Babalis; E Bagkeris; FA Post; M Boffito; I Williams; J Vera; M Johnson; J Anderson; M Sachikonye; A Winston; C Sabin; PWG Mallon
• Keywords: Cross-sectional study; Poppy

Objectives The aims of the study were to describe prevalence obesity in Pharmacokinetic and Clinical Observations People over Fifty (POPPY) cohort, identify demographic, clinical HIV‐specific factors associated with obesity, characterize association between sociodemographic, quality life (QoL). Methods A cross‐sectional analysis was carried out baseline data from three groups [“older” people HIV infection (PWH) aged ≥ 50 years, “younger” PWH < years HIV‐negative controls years] within POPPY cohort. Obesity defined as a body mass index (BMI) > 30 kg/m 2 . Results total 1361 subjects included study, whom 335 (24.6%) obese. higher (22.3%) than older (16.8%) younger (14.2%) PWH, no differences two PWH. Factors age, female gender, black African ethnicity alcohol consumption. Recreational drug use current CD4 T‐cell count (in PWH) lower odds being obese, respectively. presence worse physical health QoL scores, having cardiovascular disease, type diabetes hypertension, but osteopenia/osteoporosis, irrespective status. Conclusions Despite specific subgroups (women, origin people) more likely be negative consequences evident, regardless Whether targeted preventive strategies can reduce burden its complications remains determined.