Lipidomic analysis of facial skin surface lipids in acne in young women

• DOI: 10.1111/ics.12942
• Publication Date: 2024-01-17T05:53:30Z
• Authors: Qianqian Su; Xueqing Hu; Manli Yang; Huaming He; Yan Jia
• Keywords: Adult; Adolescent; Lipids; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Face; Acne Vulgaris; Lipidomics; Humans; Female; Skin

Abstract Background Alterations in the secretion and composition of skin surface lipids (SSL) are closely associated with development acne. Lipidomics is a useful tool to analyse SSL different types Our previous study found that phosphatidylserine triacylglycerols dominate changes male acne infantile acne, respectively. However, as well specific female patients remain be investigated. Objectives To compare profile women healthy discuss involvement differential development. Methods Systematic lipidomics approach (high‐throughput UPLC‐QTOF‐MS technology combination multivariate data analysis methods) was used variations between groups. Results Analysis revealed significant differences lipid content two Further showed levels 13 individual were significantly followed same trend main class subclasses. The largest contributor subgroup triglycerides (TG) phosphatidylinositol (PI). In addition, exhibited reduced ceramide chain length (CCL) increased unsaturated fatty acids (UFAs), CCL identical Conclusions There higher level TG PI patients. A reduction an increase UFAs might contribute barrier function results suggest may have pathogenesis than