Clinicopathological Features in Endometrial Carcinoma Associated With Lynch Syndrome in China

• DOI: 10.1111/igc.0b013e3181a12fb9
• Publication Date: 2010-12-03T18:53:16Z
• Authors: Yingmei Wang; Fengxia Xue; Russell R. Broaddus; Xia Tao; Su-su Xie; Yanbin Zhu
• Keywords: Lynch Syndrome

<h3>Objective:</h3> To study the clinicopathological characteristics of Lynch syndrome-associated endometrial carcinoma in China. <h3>Methods:</h3> Twenty-seven patients who fulfilled Amsterdam criteria II were classified as having (group A), and 331 without a family history cancer sporadic B). <h3>Results:</h3> There 81 malignancies 27 families with carcinoma, including colorectal (24.7%), (21.0%), liver (12.3%), stomach (9.9%), lung (6.2%), breast (6.2%) cancers. Mean age at time diagnosis was 49.7 years group A 56.3 B (<i>P</i> = 0.004). Second primary cancers occurred 33.3% 5.1% 0.000). The most common second (44%) ovarian (22%). percentage obese higher (<i>P</i>= 0.013). no difference between 2 groups incidence diabetes mellitus or hypertension histological type International Federation Gynecology Obstetrics stage. 5-year survival rates for 96.2% 79.6%, respectively. Prognosis better than 0.045). <h3>Conclusions:</h3> Some features such early onset multiple carcinomas are similar Chinese American/European populations. However, population had unique distribution that included Well-differentiated grade good prognosis imply biobehavior population.