Annexin IV is Differentially Expressed in Clear Cell Carcinoma of the Ovary

• DOI: 10.1111/igc.0b013e3181a844c8
• Publication Date: 2010-12-03T19:12:38Z
• Authors: Yi Miao; Bin Cai; Ling Liu; Yixia Yang; Xiaoping Wan
• Keywords: Serous carcinoma; Clear cell carcinoma

Objective: To investigate the genes that were differentially expressed between clear cell carcinoma (CCC) and serous (SAC) of ovary with complementary DNA microarray. Methods: Complementary microarray was carried out in 8 CCCs SACs ovary. Differentially identified verified by real-time polymerase chain reaction. The expression protein also immunohistochemistry Western blot cells tissues ovarian CCC. Results: Comparison gene profiling 21 more than 2-fold different CCC SAC up-regulated down-regulated 9 12, respectively. verification Annexin IV line accordance result Conclusions: technique is a feasible way to explore difference 2 types carcinoma. overexpression may be an CCC-specific molecular marker. Abbreviations: CCC- carcinoma, SAC- PCR- reaction, RT-PCR- reverse transcriptase PCR, ABCF2- ATP-binding cassette, sub-family F- member 2, HNF-1b- hepatocyte nuclear factor 1β