Study of gut microbiome in Egyptian patients with autoimmune thyroid diseases

• DOI: 10.1111/ijcp.14038
• Publication Date: 2021-01-23T05:21:43Z
• Authors: Hanaa T. El‐Zawawy; Shwikar M. Ahmed; Eman A. El‐Attar; Asmaa A. Ahmed; Yara S. Roshdy; Doaa A. Header
• Keywords: Dysbiosis; Faecalibacterium prausnitzii; Trab; Autoimmune thyroiditis; Pathogenesis

Background Hashimoto's thyroiditis (HT) and Graves’ disease (GD) are the most prevalent forms of autoimmune thyroid disorders (ATD). A pathogenic link with gut microbial dysbiosis has been described in different but not yet fully elucidated patients ATD. Aim work The present study aimed to elucidate changes microbiome Egyptian Patients Methods bacterial composition 20 ATD 30 age, sex, BMI-matched healthy subjects as controls was analysed using Quantitative SYBR Green Real-Time PCR technique targeting 16S rRNA selected genera and/or species. Results Compared controls; Firmictus/Bacteroidetes ratio (known be representative for status) significantly decreased (P < .001), without a significant difference between GD HT patients. Also, relative abundance beneficial bacteria associated barrier anti-inflammatory state; A. mucinophilia, Bifidobacterium, Lactobacillus, F. prausnitzii, were TRAb anti-TPO showed positive correlation Bacteroidetes = .001) .018), respectively. Conclusion show that can related pathogenesis This hopefully points potential therapeutic benefits manipulating management or even protection from