Evaluation of candidal colonization and specific humoral responses againstCandida albicansin patients with psoriasis

• DOI: 10.1111/ijd.12562
• Publication Date: 2014-11-26T14:36:58Z
• Authors: Mehdi Taheri Sarvtin; Tahereh Shokohi; Zohreh Hajheydari; Jamshid Yazdani; Mohammad T. Hedayati
• Keywords: Adult; Male; 0301 basic medicine; Mouth; 0303 health sciences; Adolescent; Immunoglobulins; Middle Aged; Severity of Illness Index; Immunoglobulin A; 3. Good health; Young Adult; 03 medical and health sciences; Immunoglobulin M; Case-Control Studies; Immunoglobulin G; Candida albicans; Carrier State; Humans; Psoriasis; Female; Child; Aged; Skin

Abstract Background Psoriasis is an inflammatory skin disease that can considerably affect a patient's quality of life. Environmental and genetic factors, as well superantigens toxins from Candida species, may play various roles in the exacerbation persistence psoriasis. In present study, we evaluated candidal colonization specific humoral responses against albicans patients with Methods A total 100 psoriasis vulgaris 50 healthy control individuals were enrolled study. Skin oral specimens all participants cultured on CHROMagar medium. Isolated yeast‐like fungi identified using sequence D1/D2 domain 26S rRNA gene. Enzyme‐linked immunosorbent assays (ELISAs) used to detect immunoglobulin M (IgM), IgA, IgG antibodies C. sera individuals. Results species isolated 15% 4% controls 60% 20% controls. There was significant difference between ( P < 0.05). Serum IgM, levels significantly lower than no association serum or frequency clinical severity > Conclusions The results study show higher rate comparison reduction immune patients.