Development and characterisation of a novel krill oil nanostructured lipid carrier based on 1,3‐glycerol distearate

• DOI: 10.1111/ijfs.14683
• Publication Date: 2020-06-24T10:48:06Z
• Authors: Yunwei Lin; Wenting Yin; Guoqin Liu
• Keywords: Zeta potential; Dispersity; Sonication; Ingredient; Particle (ecology)

Summary A novel nanostructured lipid carrier (NLC) loaded with Antarctic krill oil while using 1,3‐glycerol distearate (GDS) as the solid was prepared through ultrasonication. The NLCs were optimised for ingredient formulation by single‐factor experiment on basis of their effects particle size and polydispersity index (PDI) NLCs. 2% (w/w) lecithin 10% phase which accounted 50% applied to develop NLC dispersion. size, PDI zeta potential this 112 nm, 0.270 −30.8 mV, respectively, indicating good dispersion uniformity stability. Transmission electron microscopy (TEM) revealed that particles spherical uniformly dispersed without apparent aggregation. Differential calorimetry scanning (DSC) X‐ray diffraction (XRD) showed had less‐ordered crystalline structure contributing high entrapment efficiency (> 99%) EPA DHA.