Youth prediabetes and type 2 diabetes: Risk factors and prevalence of dysglycaemia

• DOI: 10.1111/ijpo.12841
• Publication Date: 2021-08-10T23:59:30Z
• Authors: Mohamed Saleh; Joon Young Kim; Christine March; Nour Gebara; Silva Arslanian
• Keywords: Prediabetes; Impaired fasting glucose

Summary Background The American Diabetes Association recommends risk‐based screening for dysglycaemia (prediabetes and type 2 diabetes) in youth with overweight/obesity plus ≥1 risk factor. However, evidence these recommendations is lacking. Objectives Examine the association between number of factors prevalence at initial presentation. Methods In a paediatric obesity registry, (>10 <20 years old, body mass index ≥85th percentile) were categorized into four groups according to (1, 2, 3 ≥4). Based on oral glucose tolerance test, participants classified normal or dysglycaemia. Results Of 635 youth, 31.5% had prediabetes 6.1% diabetes. was 23.1% 1 factor increased 44.9% ≥4 ( p = 0.025). Dyslipidaemia, family history diabetes maternal gestational significantly associated Fasting 2‐h insulin, (all < 0.0001) ALT 0.001) increasing factors. Insulin sensitivity β‐cell function deteriorated Conclusion Screening any additional warranted target early management.